Semiconducting Perylene Diimide J‐aggregates Cross‐linked Hydrogel Enables High‐Efficiency Photothermal Controlled Release of Nitric Oxide for Antibiofilm Therapy
Antibiofilm treatment, particularly drug‐containing wound healing dressings, does not typically penetrate the robust protective extracellular polymeric substance of biofilm and eradicate the bacteria. Here, a rational design of nitric oxide (NO) donor N,N'‐di‐sec‐butyl‐N,N'‐dinitroso‐1,4‐phenylenediamine (BNN6)‐based injectable hydrogel, is reported in which the NO release can be triggered by a photothermal effect owing to semiconducting perylene diimide (PDI) J‐aggregation fibers. The synthetic PDI derivatives self‐assembling into 0D nanoparticles and then aggregating to 1D J fiber is accompanied by absorbance red‐shifting from 700 to 790 nm and then to 852 nm. After encapsulating BNN6, a “sandwich roll” (SR) like structure is evenly crosslinked into an injectable hydrogel (SRH) exhibiting a high photothermal convenience efficiency of 72%, which enables the SRH to achieve highly efficient photocontrol NO release. The SRH shows excellent injectability, shape adaptability, and effective antibacterial efficacy over 99% to the E.coli and S. aureus. and remarkable in vivo antibiofilm efficiency of 99.58% by laser irradiation. Furthermore, the synergistic treatment displays the ability to eliminate inflammation, facilitate angiogenesis, and promote collagen deposition, thereby significantly stimulating the healing process of wounds. The semiconducting J‐aggregation injectable hydrogel can be a versatile strategy for the treatment of biofilm.
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